Drug interactions
Gliclazide + Nitazoxanide
Severity: Minor
Gliclazide and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of nitazoxanide, tizoxanide, is highly protein bound, so displacement of other highly bound drugs is theoretically possible. No clinically significant interaction with gliclazide has been shown, and nitazoxanide is used only for short courses.
What this interaction means in plain words
Gliclazide and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites.
What to do
No routine adjustment is needed; advise the patient to report hypoglycemia symptoms during the short treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Gliclazide with Nitazoxanide?
MediHelp rates the interaction as minor. Gliclazide and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of nitazoxanide, tizoxanide, is highly protein bound, so displacement of other highly bound drugs is theoretically possible. No clinically significant interaction with gliclazide has been shown, and nitazoxanide is used only for short courses.
How serious is the interaction between Gliclazide and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; advise the patient to report hypoglycemia symptoms during the short treatment course.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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