Drug interactions
Gliclazide + Risperidone
Severity: Moderate
Gliclazide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause weight gain and impaired glucose tolerance, which may reduce the effectiveness of gliclazide. Glycemic control can worsen, especially early in antipsychotic treatment.
What this interaction means in plain words
Gliclazide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics may induce insulin resistance and metabolic changes that oppose the antidiabetic effect (pharmacodynamic antagonism).
What to do
Monitor fasting glucose and HbA1c after starting risperidone and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Gliclazide with Risperidone?
MediHelp rates the interaction as moderate. Gliclazide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause weight gain and impaired glucose tolerance, which may reduce the effectiveness of gliclazide. Glycemic control can worsen, especially early in antipsychotic treatment.
How serious is the interaction between Gliclazide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting risperidone and adjust the antidiabetic regimen as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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