Drug interactions
Gliclazide + Rucaparib
Severity: Moderate
Gliclazide and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 and may raise gliclazide exposure. This could increase hypoglycemia risk.
What this interaction means in plain words
Gliclazide and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C9, reducing gliclazide metabolism.
What to do
Monitor blood glucose and consider reducing the gliclazide dose during rucaparib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Gliclazide with Rucaparib?
MediHelp rates the interaction as moderate. Gliclazide and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C9 and may raise gliclazide exposure. This could increase hypoglycemia risk.
How serious is the interaction between Gliclazide and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider reducing the gliclazide dose during rucaparib therapy.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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