Drug interactions
Glimepiride + Iloperidone
Severity: Moderate
Glimepiride and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and worsen glycemic control in people with diabetes. Iloperidone may therefore reduce the effectiveness of glimepiride.
What this interaction means in plain words
Glimepiride and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics can promote insulin resistance and weight gain, producing pharmacodynamic opposition to the antidiabetic drug.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glimepiride with Iloperidone?
MediHelp rates the interaction as moderate. Glimepiride and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and worsen glycemic control in people with diabetes. Iloperidone may therefore reduce the effectiveness of glimepiride.
How serious is the interaction between Glimepiride and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and adjust antidiabetic therapy as needed.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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