Drug interactions
Glimepiride + Imidapril
Severity: Moderate
Glimepiride and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mainly early in combined therapy.
What this interaction means in plain words
Glimepiride and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity, adding to the glucose-lowering effect of glimepiride.
What to do
Monitor blood glucose when imidapril is started or adjusted. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Glimepiride with Imidapril?
MediHelp rates the interaction as moderate. Glimepiride and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mainly early in combined therapy.
How serious is the interaction between Glimepiride and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imidapril is started or adjusted. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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