Drug interactions
Glimepiride + Ivacaftor
Severity: Minor
Glimepiride and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a weak inhibitor of CYP2C9 in vitro, which could modestly raise exposure to CYP2C9 substrates such as glimepiride. The clinical effect is expected to be small, but a sulfonylurea with a raised level could cause hypoglycemia.
What this interaction means in plain words
Glimepiride and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP2C9 by ivacaftor may reduce the metabolic clearance of glimepiride.
What to do
Monitor blood glucose when ivacaftor is started or stopped in a patient on glimepiride. Lower the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Ivacaftor?
MediHelp rates the interaction as minor. Glimepiride and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a weak inhibitor of CYP2C9 in vitro, which could modestly raise exposure to CYP2C9 substrates such as glimepiride. The clinical effect is expected to be small, but a sulfonylurea with a raised level could cause hypoglycemia.
How serious is the interaction between Glimepiride and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ivacaftor is started or stopped in a patient on glimepiride. Lower the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Ivacaftor?
MediHelp also lists interactions of Ivacaftor with, for example, Ensitrelvir, Apalutamide, Carbamazepine. The full list is on the Ivacaftor page.
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