Drug interactions
Glimepiride + Liraglutide
Severity: Moderate
Glimepiride and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with glimepiride increases the risk of hypoglycemia, which can be severe. The risk is highest during initiation and dose escalation.
What this interaction means in plain words
Glimepiride and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of GLP-1 receptor-mediated insulin secretion and sulfonylurea-induced insulin release.
What to do
Consider reducing the glimepiride dose when starting liraglutide. Monitor blood glucose closely during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Liraglutide
Frequently asked questions
Can I take Glimepiride with Liraglutide?
MediHelp rates the interaction as moderate. Glimepiride and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide with glimepiride increases the risk of hypoglycemia, which can be severe. The risk is highest during initiation and dose escalation.
How serious is the interaction between Glimepiride and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when starting liraglutide. Monitor blood glucose closely during titration.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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