Drug interactions
Glimepiride + Lornoxicam
Severity: Moderate
Glimepiride and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam is metabolized by CYP2C9, and NSAIDs may potentiate the hypoglycemic effect of sulfonylureas. The evidence is limited and any effect is usually modest.
What this interaction means in plain words
Glimepiride and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Possible competition at CYP2C9 and protein binding; not firmly established.
What to do
Monitor blood glucose when lornoxicam is started or stopped. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Lornoxicam
Frequently asked questions
Can I take Glimepiride with Lornoxicam?
MediHelp rates the interaction as moderate. Glimepiride and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam is metabolized by CYP2C9, and NSAIDs may potentiate the hypoglycemic effect of sulfonylureas. The evidence is limited and any effect is usually modest.
How serious is the interaction between Glimepiride and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lornoxicam is started or stopped. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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