Drug interactions
Glimepiride + Lurasidone
Severity: Moderate
Glimepiride and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and impair glucose control. This may reduce the effectiveness of glimepiride, although lurasidone has comparatively low metabolic liability.
What this interaction means in plain words
Glimepiride and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related impairment of insulin sensitivity and glucose regulation opposes sulfonylurea effects.
What to do
Monitor blood glucose and HbA1c when lurasidone is started or changed. Adjust the glimepiride dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Lurasidone?
MediHelp rates the interaction as moderate. Glimepiride and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and impair glucose control. This may reduce the effectiveness of glimepiride, although lurasidone has comparatively low metabolic liability.
How serious is the interaction between Glimepiride and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when lurasidone is started or changed. Adjust the glimepiride dose as needed.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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