Drug interactions
Glimepiride + Mefenamic acid
Severity: Moderate
Glimepiride and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may increase the glucose-lowering effect of glimepiride, raising hypoglycemia risk. Mefenamic acid inhibits CYP2C9, the enzyme that clears glimepiride.
What this interaction means in plain words
Glimepiride and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated glimepiride metabolism and possible protein binding displacement.
What to do
Monitor blood glucose more closely when starting or stopping mefenamic acid and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Mefenamic acid?
MediHelp rates the interaction as moderate. Glimepiride and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may increase the glucose-lowering effect of glimepiride, raising hypoglycemia risk. Mefenamic acid inhibits CYP2C9, the enzyme that clears glimepiride.
How serious is the interaction between Glimepiride and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting or stopping mefenamic acid and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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