Drug interactions
Glimepiride + Moxifloxacin
Severity: Moderate
Glimepiride and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin can cause significant hypoglycemia or hyperglycemia, and the risk of low glucose is higher with sulfonylureas such as glimepiride. Elderly patients and those with renal impairment are most vulnerable.
What this interaction means in plain words
Glimepiride and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones stimulate insulin release via beta-cell potassium channel effects, additive to the sulfonylurea.
What to do
Monitor blood glucose frequently when starting moxifloxacin and educate the patient on hypoglycemia. Reduce the glimepiride dose or change antibiotic if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Moxifloxacin?
MediHelp rates the interaction as moderate. Glimepiride and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin can cause significant hypoglycemia or hyperglycemia, and the risk of low glucose is higher with sulfonylureas such as glimepiride. Elderly patients and those with renal impairment are most vulnerable.
How serious is the interaction between Glimepiride and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting moxifloxacin and educate the patient on hypoglycemia. Reduce the glimepiride dose or change antibiotic if glucose becomes unstable.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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