Drug interactions
Glimepiride + Peginterferon alfa 2b
Severity: Moderate
Glimepiride and Peginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may alter CYP2C9 activity and change glimepiride exposure. Interferon can also affect glucose homeostasis, so glycemic control may become less predictable.
What this interaction means in plain words
Glimepiride and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2C9 metabolism of glimepiride; not firmly established.
What to do
Monitor blood glucose more closely when starting or stopping peginterferon. Adjust the glimepiride dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Peginterferon alfa 2b
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Peginterferon alfa 2b?
MediHelp rates the interaction as moderate. Glimepiride and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa 2b may alter CYP2C9 activity and change glimepiride exposure. Interferon can also affect glucose homeostasis, so glycemic control may become less predictable.
How serious is the interaction between Glimepiride and Peginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting or stopping peginterferon. Adjust the glimepiride dose as needed.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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