Drug interactions
Glimepiride + Piroxicam
Severity: Moderate
Glimepiride and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. Glimepiride is a CYP2C9 substrate and highly protein bound.
What this interaction means in plain words
Glimepiride and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible displacement from protein binding and competition for CYP2C9 metabolism, with NSAID effects on prostaglandin-mediated insulin secretion.
What to do
Monitor blood glucose when piroxicam is started or stopped and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Piroxicam?
MediHelp rates the interaction as moderate. Glimepiride and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. Glimepiride is a CYP2C9 substrate and highly protein bound.
How serious is the interaction between Glimepiride and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when piroxicam is started or stopped and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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