Drug interactions
Glimepiride + Tipranavir
Severity: Moderate
Glimepiride and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glycemic control achieved with glimepiride. Tipranavir/ritonavir may also alter sulfonylurea exposure through enzyme effects.
What this interaction means in plain words
Glimepiride and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose metabolism oppose sulfonylurea action, with possible CYP-mediated changes in glimepiride levels.
What to do
Monitor blood glucose and HbA1c after starting tipranavir and titrate glimepiride or add other antidiabetic therapy as needed. Watch for hypoglycemia if the protease inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Glimepiride with Tipranavir?
MediHelp rates the interaction as moderate. Glimepiride and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glycemic control achieved with glimepiride. Tipranavir/ritonavir may also alter sulfonylurea exposure through enzyme effects.
How serious is the interaction between Glimepiride and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting tipranavir and titrate glimepiride or add other antidiabetic therapy as needed. Watch for hypoglycemia if the protease inhibitor is stopped.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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