Drug interactions
Glimepiride-pioglitazone + Posaconazole
Severity: Moderate
Glimepiride-pioglitazone and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor, and azole antifungals can also raise sulfonylurea levels. Pioglitazone is partly metabolized by CYP3A4, and glimepiride by CYP2C9, so glucose-lowering effects and hypoglycemia risk may increase.
What this interaction means in plain words
Glimepiride-pioglitazone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2C9) reduces metabolism of pioglitazone and glimepiride.
What to do
Monitor blood glucose during azole therapy and reduce the glimepiride dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Posaconazole?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor, and azole antifungals can also raise sulfonylurea levels. Pioglitazone is partly metabolized by CYP3A4, and glimepiride by CYP2C9, so glucose-lowering effects and hypoglycemia risk may increase.
How serious is the interaction between Glimepiride-pioglitazone and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during azole therapy and reduce the glimepiride dose if hypoglycemia develops.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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