Drug interactions
Glimepiride-pioglitazone + Teriflunomide
Severity: Moderate
Glimepiride-pioglitazone and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide weakly inhibits CYP2C8, the main enzyme metabolizing pioglitazone, and may raise pioglitazone exposure. It also may affect CYP2C9 substrates such as glimepiride, increasing the risk of fluid retention or hypoglycemia.
What this interaction means in plain words
Glimepiride-pioglitazone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 reduces pioglitazone clearance.
What to do
Monitor for edema and blood glucose changes, and reduce the pioglitazone or glimepiride dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Teriflunomide
Frequently asked questions
Can I take Glimepiride-pioglitazone with Teriflunomide?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide weakly inhibits CYP2C8, the main enzyme metabolizing pioglitazone, and may raise pioglitazone exposure. It also may affect CYP2C9 substrates such as glimepiride, increasing the risk of fluid retention or hypoglycemia.
How serious is the interaction between Glimepiride-pioglitazone and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for edema and blood glucose changes, and reduce the pioglitazone or glimepiride dose if needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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