Drug interactions
Glimepiride-pioglitazone + Ubrogepant
Severity: Minor
Glimepiride-pioglitazone and Ubrogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is reported to induce CYP3A4 weakly. Any fall in ubrogepant exposure is likely small and of uncertain clinical importance.
What this interaction means in plain words
Glimepiride-pioglitazone and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Ubrogepant belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 induction by pioglitazone increases ubrogepant metabolism.
What to do
No dose change is usually needed. Watch for reduced migraine relief.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Ubrogepant?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is reported to induce CYP3A4 weakly. Any fall in ubrogepant exposure is likely small and of uncertain clinical importance.
How serious is the interaction between Glimepiride-pioglitazone and Ubrogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for reduced migraine relief.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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