Drug interactions
Ketoconazole + Ubrogepant
Severity: Contraindicated
Ketoconazole and Ubrogepant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole markedly raises ubrogepant exposure, which could increase adverse effects. Labeling contraindicates strong CYP3A4 inhibitors with ubrogepant.
What this interaction means in plain words
Ketoconazole and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Ubrogepant belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition decreases ubrogepant clearance.
What to do
Do not combine. Use an alternative acute migraine therapy while on ketoconazole.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
- Carbamazepine + Ubrogepant Major
Frequently asked questions
Can I take Ketoconazole with Ubrogepant?
MediHelp rates the interaction as contraindicated. Ketoconazole and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly raises ubrogepant exposure, which could increase adverse effects. Labeling contraindicates strong CYP3A4 inhibitors with ubrogepant.
How serious is the interaction between Ketoconazole and Ubrogepant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative acute migraine therapy while on ketoconazole.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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