Drug interactions
Itraconazole + Ubrogepant
Severity: Contraindicated
Itraconazole and Ubrogepant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole considerably increases ubrogepant exposure, which may heighten adverse effects such as nausea, somnolence and dry mouth. Ubrogepant labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Itraconazole and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Ubrogepant belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces ubrogepant clearance.
What to do
Avoid ubrogepant during itraconazole therapy; use an alternative acute migraine treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
- Carbamazepine + Ubrogepant Major
Frequently asked questions
Can I take Itraconazole with Ubrogepant?
MediHelp rates the interaction as contraindicated. Itraconazole and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole considerably increases ubrogepant exposure, which may heighten adverse effects such as nausea, somnolence and dry mouth. Ubrogepant labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Ubrogepant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ubrogepant during itraconazole therapy; use an alternative acute migraine treatment.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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