Drug interactions
Posaconazole + Ubrogepant
Severity: Contraindicated
Posaconazole and Ubrogepant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole substantially increases ubrogepant exposure, which may increase adverse effects such as nausea and somnolence.
What this interaction means in plain words
Posaconazole and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Posaconazole belongs to Anti Fungals; Ubrogepant belongs to Central Nervous System.
Why it happens
Posaconazole strongly inhibits CYP3A4, the main metabolic route for ubrogepant.
What to do
Do not co-administer, as labeling prohibits strong CYP3A4 inhibitors. Use a different acute migraine treatment during posaconazole therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
- Carbamazepine + Ubrogepant Major
Frequently asked questions
Can I take Posaconazole with Ubrogepant?
MediHelp rates the interaction as contraindicated. Posaconazole and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole substantially increases ubrogepant exposure, which may increase adverse effects such as nausea and somnolence.
How serious is the interaction between Posaconazole and Ubrogepant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, as labeling prohibits strong CYP3A4 inhibitors. Use a different acute migraine treatment during posaconazole therapy.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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