Drug interactions
Ubrogepant + Voriconazole
Severity: Contraindicated
Ubrogepant and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole substantially increases ubrogepant exposure, which may increase adverse effects such as nausea, somnolence and hypersensitivity reactions.
What this interaction means in plain words
Ubrogepant and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ubrogepant belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces ubrogepant clearance.
What to do
Do not co-administer, as ubrogepant labeling contraindicates strong CYP3A4 inhibitors. Use an alternative acute migraine therapy during voriconazole treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Apalutamide + Ubrogepant Major
- Carbamazepine + Ubrogepant Major
Frequently asked questions
Can I take Ubrogepant with Voriconazole?
MediHelp rates the interaction as contraindicated. Ubrogepant and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole substantially increases ubrogepant exposure, which may increase adverse effects such as nausea, somnolence and hypersensitivity reactions.
How serious is the interaction between Ubrogepant and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, as ubrogepant labeling contraindicates strong CYP3A4 inhibitors. Use an alternative acute migraine therapy during voriconazole treatment.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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