Drug interactions
Clarithromycin + Ubrogepant
Severity: Contraindicated
Clarithromycin and Ubrogepant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin markedly increases ubrogepant exposure by inhibiting CYP3A4. Ubrogepant labeling contraindicates concurrent strong CYP3A4 inhibitors because of the risk of increased adverse effects such as nausea and somnolence.
What this interaction means in plain words
Clarithromycin and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ubrogepant belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition reduces ubrogepant metabolism, raising systemic concentrations.
What to do
Do not co-administer; use an alternative acute migraine therapy during the clarithromycin course or an alternative antibiotic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ubrogepant
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
- Carbamazepine + Ubrogepant Major
Frequently asked questions
Can I take Clarithromycin with Ubrogepant?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ubrogepant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly increases ubrogepant exposure by inhibiting CYP3A4. Ubrogepant labeling contraindicates concurrent strong CYP3A4 inhibitors because of the risk of increased adverse effects such as nausea and somnolence.
How serious is the interaction between Clarithromycin and Ubrogepant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative acute migraine therapy during the clarithromycin course or an alternative antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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