Drug interactions
Glipizide + Hydrochlorothiazide-valsartan
Severity: Minor
Glipizide and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and reduce the effect of glipizide. The effect is usually modest and more likely at higher thiazide doses.
What this interaction means in plain words
Glipizide and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide belongs to Endocrine; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Thiazide-induced impairment of insulin secretion and glucose tolerance opposes the sulfonylurea effect.
What to do
Monitor blood glucose after starting or changing the thiazide dose. Adjust glipizide if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Glipizide and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides can raise blood glucose and reduce the effect of glipizide. The effect is usually modest and more likely at higher thiazide doses.
How serious is the interaction between Glipizide and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the thiazide dose. Adjust glipizide if control worsens.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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