Drug interactions
Glipizide + Ibuprofen
Severity: Moderate
Glipizide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the hypoglycemic effect of glipizide in some patients. The effect is variable and usually modest with ibuprofen.
What this interaction means in plain words
Glipizide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and reduced CYP2C9-mediated clearance of the sulfonylurea; not firmly established.
What to do
Monitor blood glucose when ibuprofen is started or stopped and teach the patient hypoglycemia symptoms; lower the glipizide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Ibuprofen?
MediHelp rates the interaction as moderate. Glipizide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the hypoglycemic effect of glipizide in some patients. The effect is variable and usually modest with ibuprofen.
How serious is the interaction between Glipizide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ibuprofen is started or stopped and teach the patient hypoglycemia symptoms; lower the glipizide dose if needed.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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