Drug interactions
Glipizide + Insulin degludec
Severity: Moderate
Glipizide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glipizide with insulin has additive glucose-lowering effects and increases the risk of hypoglycemia, particularly with missed meals or renal impairment.
What this interaction means in plain words
Glipizide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Additive effect: sulfonylurea-stimulated endogenous insulin release plus exogenous insulin.
What to do
Monitor blood glucose closely and reduce the glipizide or insulin degludec dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Insulin degludec?
MediHelp rates the interaction as moderate. Glipizide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glipizide with insulin has additive glucose-lowering effects and increases the risk of hypoglycemia, particularly with missed meals or renal impairment.
How serious is the interaction between Glipizide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glipizide or insulin degludec dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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