Drug interactions
Glipizide + Miconazole
Severity: Moderate
Glipizide and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glipizide is cleared mainly by CYP2C9, which miconazole inhibits. Higher glipizide levels can cause hypoglycemia, which may be prolonged. Systemic absorption from vaginal products is limited but has been linked to such effects with sulfonylureas.
What this interaction means in plain words
Glipizide and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP2C9, decreasing glipizide metabolism.
What to do
Increase blood glucose monitoring during and shortly after miconazole therapy. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Miconazole?
MediHelp rates the interaction as moderate. Glipizide and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glipizide is cleared mainly by CYP2C9, which miconazole inhibits. Higher glipizide levels can cause hypoglycemia, which may be prolonged. Systemic absorption from vaginal products is limited but has been linked to such effects with sulfonylureas.
How serious is the interaction between Glipizide and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring during and shortly after miconazole therapy. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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