Drug interactions
Glipizide + Rasagiline
Severity: Minor
Glipizide and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been linked to enhanced glucose lowering with sulfonylureas, raising hypoglycemia risk. Evidence for selective MAO-B inhibitors such as rasagiline is limited.
What this interaction means in plain words
Glipizide and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
The mechanism is not established.
What to do
Monitor blood glucose when rasagiline is started. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Rasagiline?
MediHelp rates the interaction as minor. Glipizide and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors have been linked to enhanced glucose lowering with sulfonylureas, raising hypoglycemia risk. Evidence for selective MAO-B inhibitors such as rasagiline is limited.
How serious is the interaction between Glipizide and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rasagiline is started. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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