Drug interactions
Glipizide-metformin + Hydrochlorothiazide
Severity: Moderate
Glipizide-metformin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effect of glipizide and metformin, particularly at higher doses. Dehydration or reduced renal function from the diuretic may also increase metformin exposure.
What this interaction means in plain words
Glipizide-metformin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides cause hypokalemia-related impairment of insulin secretion and insulin resistance, and may compete with metformin for renal tubular secretion.
What to do
Monitor blood glucose, potassium and renal function, and adjust antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Glipizide-metformin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Glipizide-metformin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effect of glipizide and metformin, particularly at higher doses. Dehydration or reduced renal function from the diuretic may also increase metformin exposure.
How serious is the interaction between Glipizide-metformin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function, and adjust antidiabetic therapy as required.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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