Drug interactions
Glipizide-metformin + Levoketoconazole
Severity: Moderate
Glipizide-metformin and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP2C9 and other enzymes, and may increase glipizide exposure, which raises the risk of hypoglycemia. Levoketoconazole is also used in Cushing syndrome, where glucose levels may change as cortisol falls.
What this interaction means in plain words
Glipizide-metformin and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated glipizide metabolism increases sulfonylurea exposure.
What to do
Monitor blood glucose closely and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Levoketoconazole?
MediHelp rates the interaction as moderate. Glipizide-metformin and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP2C9 and other enzymes, and may increase glipizide exposure, which raises the risk of hypoglycemia. Levoketoconazole is also used in Cushing syndrome, where glucose levels may change as cortisol falls.
How serious is the interaction between Glipizide-metformin and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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