Drug interactions
Glipizide-metformin + Linagliptin
Severity: Moderate
Glipizide-metformin and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding linagliptin to a sulfonylurea such as glipizide increases the incidence of hypoglycemia compared with the sulfonylurea alone. Metformin and linagliptin are commonly combined without this problem.
What this interaction means in plain words
Glipizide-metformin and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
DPP-4 inhibition raises glucose-dependent insulin secretion, which adds to the insulin release driven by the sulfonylurea.
What to do
Consider reducing the glipizide dose when linagliptin is started, and educate the patient about hypoglycemia symptoms and home glucose monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Glipizide-metformin with Linagliptin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding linagliptin to a sulfonylurea such as glipizide increases the incidence of hypoglycemia compared with the sulfonylurea alone. Metformin and linagliptin are commonly combined without this problem.
How serious is the interaction between Glipizide-metformin and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glipizide dose when linagliptin is started, and educate the patient about hypoglycemia symptoms and home glucose monitoring.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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