Drug interactions
Glipizide-metformin + Lopinavir
Severity: Moderate
Glipizide-metformin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir is associated with insulin resistance and hyperglycemia, which may reduce the effect of glipizide and metformin. Glipizide exposure may also change because of altered CYP-mediated metabolism, making the net effect unpredictable.
What this interaction means in plain words
Glipizide-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance plus possible modulation of CYP2C9 metabolism of glipizide.
What to do
Monitor blood glucose regularly after lopinavir is started or stopped and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Lopinavir?
MediHelp rates the interaction as moderate. Glipizide-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir is associated with insulin resistance and hyperglycemia, which may reduce the effect of glipizide and metformin. Glipizide exposure may also change because of altered CYP-mediated metabolism, making the net effect unpredictable.
How serious is the interaction between Glipizide-metformin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after lopinavir is started or stopped and adjust antidiabetic doses as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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