Drug interactions
Glipizide-metformin + Metolazone
Severity: Moderate
Glipizide-metformin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, a thiazide-like diuretic, can raise blood glucose and reduce the effect of glipizide and metformin. Strong diuresis may also cause volume depletion and renal impairment, increasing metformin exposure.
What this interaction means in plain words
Glipizide-metformin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia impairs insulin secretion and promotes insulin resistance.
What to do
Monitor blood glucose, potassium and renal function and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Metolazone
Frequently asked questions
Can I take Glipizide-metformin with Metolazone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, a thiazide-like diuretic, can raise blood glucose and reduce the effect of glipizide and metformin. Strong diuresis may also cause volume depletion and renal impairment, increasing metformin exposure.
How serious is the interaction between Glipizide-metformin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function and adjust antidiabetic therapy as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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