Drug interactions
Glipizide-metformin + Nitazoxanide
Severity: Minor
Glipizide-metformin and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of nitazoxanide, tizoxanide, is highly protein bound, so displacement of other highly bound drugs such as glipizide is theoretically possible. Clinically significant hypoglycemia has not been well documented.
What this interaction means in plain words
Glipizide-metformin and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites between tizoxanide and glipizide.
What to do
No routine change is needed for a short course of nitazoxanide. Counsel the patient to recognize hypoglycemia symptoms and check glucose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Nitazoxanide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Glipizide-metformin with Nitazoxanide?
MediHelp rates the interaction as minor. Glipizide-metformin and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of nitazoxanide, tizoxanide, is highly protein bound, so displacement of other highly bound drugs such as glipizide is theoretically possible. Clinically significant hypoglycemia has not been well documented.
How serious is the interaction between Glipizide-metformin and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for a short course of nitazoxanide. Counsel the patient to recognize hypoglycemia symptoms and check glucose if they occur.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
