Drug interactions
Glipizide-metformin + Pegvisomant
Severity: Moderate
Glipizide-metformin and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action and improves insulin sensitivity in acromegaly. Patients on glipizide and metformin may therefore develop lower glucose levels and hypoglycemia.
What this interaction means in plain words
Glipizide-metformin and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism improves insulin sensitivity, adding to the effects of antidiabetic drugs.
What to do
Monitor blood glucose closely after starting pegvisomant. Lower the glipizide dose (or other antidiabetic doses) if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Glipizide-metformin with Pegvisomant?
MediHelp rates the interaction as moderate. Glipizide-metformin and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action and improves insulin sensitivity in acromegaly. Patients on glipizide and metformin may therefore develop lower glucose levels and hypoglycemia.
How serious is the interaction between Glipizide-metformin and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting pegvisomant. Lower the glipizide dose (or other antidiabetic doses) if glucose falls.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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