Drug interactions
Glipizide-metformin + Risperidone
Severity: Moderate
Glipizide-metformin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and weight gain, which may counteract the effect of antidiabetic therapy. Patients may need more intensive glucose management.
What this interaction means in plain words
Glipizide-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics may induce insulin resistance and impair insulin secretion, opposing the glucose-lowering effects.
What to do
Monitor fasting glucose and HbA1c after starting risperidone. Adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Glipizide-metformin with Risperidone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and weight gain, which may counteract the effect of antidiabetic therapy. Patients may need more intensive glucose management.
How serious is the interaction between Glipizide-metformin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting risperidone. Adjust antidiabetic doses as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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