Drug interactions
Glipizide-metformin + Temsirolimus
Severity: Moderate
Glipizide-metformin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus commonly causes hyperglycemia and may offset the effect of antidiabetic therapy. Patients with diabetes may need more intensive treatment.
What this interaction means in plain words
Glipizide-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
mTOR inhibition causes insulin resistance and reduced insulin signaling, opposing glucose lowering.
What to do
Check glucose regularly during treatment. Increase antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Temsirolimus?
MediHelp rates the interaction as moderate. Glipizide-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus commonly causes hyperglycemia and may offset the effect of antidiabetic therapy. Patients with diabetes may need more intensive treatment.
How serious is the interaction between Glipizide-metformin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose regularly during treatment. Increase antidiabetic doses as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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