Drug interactions
Glipizide-metformin + Trimipramine
Severity: Minor
Glipizide-metformin and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may modestly lower blood glucose or alter glycemic control and can mask some hypoglycemia symptoms. Combined with glipizide, this may occasionally increase hypoglycemia, though the effect is generally small.
What this interaction means in plain words
Glipizide-metformin and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive glucose lowering and altered adrenergic symptom perception; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping trimipramine and advise patients about hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Trimipramine?
MediHelp rates the interaction as minor. Glipizide-metformin and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may modestly lower blood glucose or alter glycemic control and can mask some hypoglycemia symptoms. Combined with glipizide, this may occasionally increase hypoglycemia, though the effect is generally small.
How serious is the interaction between Glipizide-metformin and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping trimipramine and advise patients about hypoglycemia symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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