Drug interactions
Glofitamab + Olanzapine
Severity: Moderate
Glofitamab and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release, which can temporarily suppress CYP enzyme activity. Olanzapine is cleared mainly by CYP1A2, so its levels may rise and cause more sedation or other dose-related adverse effects, mostly around the first doses and during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Cytokine-mediated downregulation of CYP1A2 reduces olanzapine metabolism and raises exposure.
What to do
Monitor for increased olanzapine effects such as sedation, hypotension and anticholinergic symptoms during the first cycles and cytokine release syndrome. Reduce the olanzapine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Olanzapine?
MediHelp rates the interaction as moderate. Glofitamab and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release, which can temporarily suppress CYP enzyme activity. Olanzapine is cleared mainly by CYP1A2, so its levels may rise and cause more sedation or other dose-related adverse effects, mostly around the first doses and during cytokine release syndrome.
How serious is the interaction between Glofitamab and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased olanzapine effects such as sedation, hypotension and anticholinergic symptoms during the first cycles and cytokine release syndrome. Reduce the olanzapine dose if toxicity appears.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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