Drug interactions
Glofitamab + Phenytoin
Severity: Moderate
Glofitamab and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab-induced cytokine release may transiently suppress CYP enzyme activity, which could raise levels of narrow therapeutic index drugs like phenytoin. This is most relevant at treatment initiation and during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP enzymes reduces phenytoin clearance.
What to do
Monitor phenytoin levels and signs of toxicity during the first cycle and any cytokine release syndrome. Adjust the phenytoin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Phenytoin?
MediHelp rates the interaction as moderate. Glofitamab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab-induced cytokine release may transiently suppress CYP enzyme activity, which could raise levels of narrow therapeutic index drugs like phenytoin. This is most relevant at treatment initiation and during cytokine release syndrome.
How serious is the interaction between Glofitamab and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and signs of toxicity during the first cycle and any cytokine release syndrome. Adjust the phenytoin dose accordingly.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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