Drug interactions
Glucagon + Insulin glargine-lixisenatide
Severity: Moderate
Glucagon and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and directly opposes the glucose-lowering action of insulin glargine and lixisenatide. This is the intended effect when glucagon is used to rescue severe hypoglycemia, but it can cause hyperglycemia afterwards.
What this interaction means in plain words
Glucagon and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glucagon belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis, counteracting insulin's effects.
What to do
Monitor blood glucose after glucagon administration and give oral carbohydrate once the patient can swallow. Review insulin dosing after any severe hypoglycemic event.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Glucagon and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon raises blood glucose and directly opposes the glucose-lowering action of insulin glargine and lixisenatide. This is the intended effect when glucagon is used to rescue severe hypoglycemia, but it can cause hyperglycemia afterwards.
How serious is the interaction between Glucagon and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after glucagon administration and give oral carbohydrate once the patient can swallow. Review insulin dosing after any severe hypoglycemic event.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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