Drug interactions
Glucagon + Insulin glulisine
Severity: Minor
Glucagon and Insulin glulisine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes the effect of rapid-acting insulin, which is the intended use during hypoglycemia. Subsequent hyperglycemia can occur.
What this interaction means in plain words
Glucagon and Insulin glulisine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Insulin glulisine belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucagon increases hepatic glucose output.
What to do
Check blood glucose after glucagon and adjust insulin dosing accordingly. Give oral carbohydrate once able.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Glucagon with Insulin glulisine?
MediHelp rates the interaction as minor. Glucagon and Insulin glulisine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes the effect of rapid-acting insulin, which is the intended use during hypoglycemia. Subsequent hyperglycemia can occur.
How serious is the interaction between Glucagon and Insulin glulisine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose after glucagon and adjust insulin dosing accordingly. Give oral carbohydrate once able.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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