Drug interactions
Glyburide + Insulin glargine
Severity: Moderate
Glyburide and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide with insulin glargine causes additive glucose lowering and raises the risk of hypoglycemia, which can be prolonged in renal impairment or in older adults.
What this interaction means in plain words
Glyburide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive effect of exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor glucose and reduce the glyburide or insulin dose if hypoglycemia occurs; consider a shorter-acting sulfonylurea in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin glargine?
MediHelp rates the interaction as moderate. Glyburide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide with insulin glargine causes additive glucose lowering and raises the risk of hypoglycemia, which can be prolonged in renal impairment or in older adults.
How serious is the interaction between Glyburide and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce the glyburide or insulin dose if hypoglycemia occurs; consider a shorter-acting sulfonylurea in elderly patients.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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