Drug interactions
Glyburide + Ivacaftor
Severity: Minor
Glyburide and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite weakly inhibit P-gp and may modestly increase glyburide exposure. Glyburide is not a clinically significant CYP3A4 inhibitor, so ivacaftor exposure is unlikely to change. The main concern is mild potentiation of glucose lowering.
What this interaction means in plain words
Glyburide and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor weakly inhibits P-gp efflux, potentially increasing glyburide absorption and concentrations.
What to do
Monitor blood glucose when ivacaftor is started, particularly in patients with cystic fibrosis-related diabetes, and adjust the glyburide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Glyburide with Ivacaftor?
MediHelp rates the interaction as minor. Glyburide and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its metabolite weakly inhibit P-gp and may modestly increase glyburide exposure. Glyburide is not a clinically significant CYP3A4 inhibitor, so ivacaftor exposure is unlikely to change. The main concern is mild potentiation of glucose lowering.
How serious is the interaction between Glyburide and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ivacaftor is started, particularly in patients with cystic fibrosis-related diabetes, and adjust the glyburide dose if needed.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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