Drug interactions
Glyburide + Lasmiditan
Severity: Minor
Glyburide and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, which may increase exposure to BCRP substrates such as glyburide. The clinical effect is uncertain and probably modest with occasional lasmiditan use.
What this interaction means in plain words
Glyburide and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Lasmiditan belongs to Central Nervous System.
Why it happens
In vitro BCRP inhibition may increase glyburide absorption.
What to do
Be aware of the possibility of increased glyburide effect for several hours after a lasmiditan dose. Counsel patients on hypoglycemia symptoms and check glucose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Glyburide with Lasmiditan?
MediHelp rates the interaction as minor. Glyburide and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro, which may increase exposure to BCRP substrates such as glyburide. The clinical effect is uncertain and probably modest with occasional lasmiditan use.
How serious is the interaction between Glyburide and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the possibility of increased glyburide effect for several hours after a lasmiditan dose. Counsel patients on hypoglycemia symptoms and check glucose if symptoms occur.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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