Drug interactions
Glyburide + Lomitapide
Severity: Moderate
Glyburide and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a substrate of CYP3A4, and glyburide is a weak CYP3A4 inhibitor that may modestly raise lomitapide exposure. Higher lomitapide levels increase the risk of liver enzyme elevation, hepatic fat accumulation and gastrointestinal adverse effects.
What this interaction means in plain words
Glyburide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated lomitapide metabolism by glyburide.
What to do
Monitor liver enzymes and bilirubin per lomitapide labeling and keep the lomitapide dose within the labeled limit for patients on weak CYP3A4 inhibitors. Reduce the lomitapide dose if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide and Lomitapide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Glyburide with Lomitapide?
MediHelp rates the interaction as moderate. Glyburide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a substrate of CYP3A4, and glyburide is a weak CYP3A4 inhibitor that may modestly raise lomitapide exposure. Higher lomitapide levels increase the risk of liver enzyme elevation, hepatic fat accumulation and gastrointestinal adverse effects.
How serious is the interaction between Glyburide and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin per lomitapide labeling and keep the lomitapide dose within the labeled limit for patients on weak CYP3A4 inhibitors. Reduce the lomitapide dose if transaminases rise.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
