Drug interactions
Glyburide + Mefenamic acid
Severity: Moderate
Glyburide and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may raise glyburide exposure and enhance its glucose-lowering effect, increasing the chance of hypoglycemia. Both drugs are CYP2C9 substrates and are highly protein bound, so competition for metabolism and binding may contribute.
What this interaction means in plain words
Glyburide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Competition for CYP2C9 metabolism and plasma protein binding sites may increase free glyburide; the clinical magnitude is not well established.
What to do
Monitor blood glucose more frequently when mefenamic acid is started or stopped, and reduce the glyburide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Mefenamic acid?
MediHelp rates the interaction as moderate. Glyburide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may raise glyburide exposure and enhance its glucose-lowering effect, increasing the chance of hypoglycemia. Both drugs are CYP2C9 substrates and are highly protein bound, so competition for metabolism and binding may contribute.
How serious is the interaction between Glyburide and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when mefenamic acid is started or stopped, and reduce the glyburide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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