Drug interactions
Glyburide + Mesterolone
Severity: Minor
Glyburide and Mesterolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens like mesterolone may improve insulin sensitivity and lower glucose, adding to the effect of glyburide. This can occasionally cause hypoglycemia.
What this interaction means in plain words
Glyburide and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Mesterolone belongs to Endocrine.
Why it happens
Additive glucose lowering through androgen-related effects on insulin sensitivity; evidence is limited.
What to do
Monitor blood glucose when mesterolone is started or stopped. Lower the glyburide dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Mesterolone
Frequently asked questions
Can I take Glyburide with Mesterolone?
MediHelp rates the interaction as minor. Glyburide and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androgens like mesterolone may improve insulin sensitivity and lower glucose, adding to the effect of glyburide. This can occasionally cause hypoglycemia.
How serious is the interaction between Glyburide and Mesterolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when mesterolone is started or stopped. Lower the glyburide dose if hypoglycemia develops.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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