Drug interactions
Glyburide + Moxifloxacin
Severity: Moderate
Glyburide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin can disturb glucose control, and with glyburide there is an increased risk of severe hypoglycemia. Glyburide's long action and active metabolites make episodes more prolonged, especially in older or renally impaired patients.
What this interaction means in plain words
Glyburide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones enhance insulin release via beta-cell potassium channel effects, additive to glyburide.
What to do
Monitor blood glucose closely during therapy and educate the patient on hypoglycemia. Reduce the glyburide dose if needed or choose another antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Moxifloxacin?
MediHelp rates the interaction as moderate. Glyburide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin can disturb glucose control, and with glyburide there is an increased risk of severe hypoglycemia. Glyburide's long action and active metabolites make episodes more prolonged, especially in older or renally impaired patients.
How serious is the interaction between Glyburide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during therapy and educate the patient on hypoglycemia. Reduce the glyburide dose if needed or choose another antibiotic in high-risk patients.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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