Drug interactions
Glyburide + Piroxicam
Severity: Moderate
Glyburide and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may enhance the glucose-lowering effect of glyburide, leading to hypoglycemia in some patients. The effect is thought to be modest and variable but may be relevant in elderly patients or those with renal impairment.
What this interaction means in plain words
Glyburide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Both drugs are CYP2C9 substrates and piroxicam may compete for metabolism; NSAIDs may also have independent effects on glycemia and displace sulfonylureas from protein binding.
What to do
Monitor blood glucose when starting or stopping piroxicam in a patient taking glyburide. Reduce the glyburide dose if hypoglycemia occurs and counsel the patient on its symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Piroxicam?
MediHelp rates the interaction as moderate. Glyburide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam may enhance the glucose-lowering effect of glyburide, leading to hypoglycemia in some patients. The effect is thought to be modest and variable but may be relevant in elderly patients or those with renal impairment.
How serious is the interaction between Glyburide and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping piroxicam in a patient taking glyburide. Reduce the glyburide dose if hypoglycemia occurs and counsel the patient on its symptoms.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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