Drug interactions
Glyburide + Rosuvastatin
Severity: Minor
Glyburide and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide inhibits OATP1B1 in vitro, which could in theory raise rosuvastatin concentrations. No clear clinical increase in myopathy has been established, and the two drugs are commonly used together in diabetic patients.
What this interaction means in plain words
Glyburide and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of hepatic OATP1B1 uptake of rosuvastatin; clinical relevance is unproven.
What to do
No dose adjustment is needed. Counsel the patient to report unexplained muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Rosuvastatin?
MediHelp rates the interaction as minor. Glyburide and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide inhibits OATP1B1 in vitro, which could in theory raise rosuvastatin concentrations. No clear clinical increase in myopathy has been established, and the two drugs are commonly used together in diabetic patients.
How serious is the interaction between Glyburide and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Counsel the patient to report unexplained muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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